Status:
COMPLETED
Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea
Lead Sponsor:
Eli Lilly and Company
Conditions:
Obstructive Sleep Apnea
Obesity
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to evaluate the effect and safety of tirzepatide in participants with moderate to severe obstructive sleep apnea and obesity who are both unwilling or unable to use Positi...
Eligibility Criteria
Inclusion
- For GPI1 Participants:
- \- Participants who are unable or unwilling to use PAP therapy. Participants must not have used PAP for at least 4 weeks prior to screening.
- For GPI2 Participants:
- \- Have been on PAP therapy for at least 3 consecutive months prior to screening and plan to continue PAP therapy during the study
- For Both GPI1 and GPI2 Participants:
- Have an AHI ≥15 on PSG as part of the trial at screening
- Have a body mass index (BMI) ≥30 kilogram/square meter (kg/m²)
- Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight
Exclusion
- For GPI2 Participants:
- Have personal or job-related responsibilities, or in the opinion of the investigator have any situation, that would make it unsafe to stop PAP therapy for 7 days prior to PSG testing during the course of the study
- Are unwilling to stop PAP therapy for 7 days prior to polysomnography (PSG) testing during the course of the study
- For GPI1 and GPI2 Participants:
- Female participants must not be pregnant, intending to be pregnant, breastfeeding, or intending to breastfeed.
- Have type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM), history of ketoacidosis, or hyperosmolar state/coma.
- Have HbA1c ≥ 6.5% (≥ 48 mmol/mol) at baseline
- Any previous or planned surgery for sleep apnea or major ear, nose or throat surgery, including tonsillectomy and adenoidectomy that still may affect breathing at time of baseline
- Have significant craniofacial abnormalities that may affect breathing at baseline
- Have diagnosis of Central or Mixed Sleep Apnea with % of mixed or central apneas/hypopneas ≥50%, or diagnosis of Cheyne Stokes Respiration
- Diagnosis of Obesity Hypoventilation Syndrome or daytime hypercapnia.
- Active device treatment of OSA other than PAP therapy (for example, dental appliance), or other treatment, that in the opinion of the investigator, may interfere with study outcomes, unless willing to stop treatment at baseline and throughout the study.
- Respiratory and neuromuscular diseases that could interfere with the results of the trial in the opinion of the investigator.
- Have a self-reported change in body weight \>5 kg within 3 months prior to screening
- Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty if performed more than 1 year prior to screening)
- Have or plan to have endoscopic and/or device-based therapy for obesity or have had device removal within the last 6 months (for example, mucosal ablation, gastric artery embolization, intragastric balloon, and duodenal-jejunal bypass sleeve)
Key Trial Info
Start Date :
June 21 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 29 2024
Estimated Enrollment :
469 Patients enrolled
Trial Details
Trial ID
NCT05412004
Start Date
June 21 2022
End Date
March 29 2024
Last Update
April 30 2025
Active Locations (58)
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1
Artemis Institute for Clinical Research
Riverside, California, United States, 92503
2
Teradan Clinical Trials, LLC
Brandon, Florida, United States, 33511
3
Renstar Medical Research
Ocala, Florida, United States, 34470
4
Palm Beach Research Center
West Palm Beach, Florida, United States, 33409