Status:
UNKNOWN
Metformin to Prevent Preterm Birth in Twin Pregnancy
Lead Sponsor:
The University of Hong Kong
Conditions:
Preterm Birth
Premature Obstetric Labor
Eligibility:
FEMALE
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Preterm birth (PTB) is a major challenge to perinatal health. It accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. Neonates born preterm are also at risk o...
Eligibility Criteria
Inclusion
- All women age ≥ 18 years old
- Viable twin pregnancy with dichorionic diamnioticity or monochorionic diamnioticity
- Gestational age less than 20 completed weeks
Exclusion
- High order multiple pregnancy such as triplets or higher order multiple pregnancy with fetal reduction to twin pregnancy
- Monochorionic monoamniotic twin pregnancy
- Twin pregnancy with silent miscarriage of one twin
- Excessive vaginal bleeding
- Presence of congenital anomaly
- Rupture of membranes
- Congenital uterine anomaly
- Unwillingness or inability to comply with study procedures
- Known paternal or maternal abnormal karyotype
- Known renal, liver, or heart failure
- Pre-existing type 1 or 2 diabetes
- Treatment with metformin at the time of screening
- Allergic to metformin
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2025
Estimated Enrollment :
790 Patients enrolled
Trial Details
Trial ID
NCT05412056
Start Date
June 1 2022
End Date
June 1 2025
Last Update
June 23 2022
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