Status:
RECRUITING
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
Lead Sponsor:
Ohio State University
Conditions:
Mechanical Ventilation Complication
Hyperoxia
Eligibility:
All Genders
18-110 years
Brief Summary
The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics....
Detailed Description
This proposal will elucidate an approach for precise and safe oxygenation levels and correlation with the oxidative lipid biomarker profile of optimal oxygenation. The aim of this study is to identify...
Eligibility Criteria
Inclusion
- • Adults age =\> 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours
Exclusion
- Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others
- 2)Chronic respiratory failure prior to admission;
- 3)Hemoptysis or diffuse alveolar hemorrhage
- 4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements.
- 5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;
Key Trial Info
Start Date :
March 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05412810
Start Date
March 1 2023
End Date
September 1 2026
Last Update
April 26 2024
Active Locations (1)
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1
Ohio State University Medical Center
Columbus, Ohio, United States, 43210