Status:
COMPLETED
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lead Sponsor:
Geneplus-Beijing Co. Ltd.
Collaborating Sponsors:
Beijing Hospital
Emergency General Hospital
Conditions:
Pulmonary Nodule, Solitary
Whole-genome Methylation Sequencing
Eligibility:
All Genders
20-75 years
Brief Summary
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned. The popularization of chest CT (electronic computed to...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Male or female, 20-75 year-old with pulmonary nodules 1-3cm in diameter confirmed by chest CT;
- The nodules are single or multiple, suspected to be malignant, and have the indication of surgical resection;
- Patient accept imaging evaluation without advanced lung tumors and metastases;
- The location of the nodule in the lung is within the reach of lung biopsy under bronchoscope;
- provide the collected clinical data needed by the research;
- Patients have the ability to follow the planned schedule and actively cooperate to return to the hospital for regular clinical visits.
- Exclusion criteria:
- Unwilling to accept the invasive examination and treatment of this study;
- Contraindication of tracheoscopy;
- Consider that the pulmonary nodules are metastatic tumors or unresectable advanced lung cancer;
- Those who cannot tolerate resection of pulmonary nodules;
- Accompanied by other malignant tumors;
- In the judgment of the researcher, the patient also suffers from other serious diseases that may affect the accuracy of the test;
- Those who cannot accept the use of contrast-enhanced magnetic resonance imaging (MRI) or contrast-enhanced computed tomography (CT);
- Any other illness, social / psychological problems, etc. are judged by the researcher to be unsuitable for participating in this study.
Exclusion
Key Trial Info
Start Date :
July 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2025
Estimated Enrollment :
158 Patients enrolled
Trial Details
Trial ID
NCT05415670
Start Date
July 1 2023
End Date
August 1 2025
Last Update
September 4 2025
Active Locations (2)
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1
Emergency general hospital
Beijing, Beijing Municipality, China, 100028
2
Beijing hospital
Beijing, Beijing Municipality, China, 100730