Status:
COMPLETED
Autonomic Neuromodulation by Transcutaneous Nerve Stimulation in Acute Ischaemic Stroke.
Lead Sponsor:
Queen Mary University of London
Conditions:
Ischemic Stroke
Thrombotic Stroke
Eligibility:
All Genders
18-95 years
Phase:
NA
Brief Summary
Autonomic modulation by transcutaneous vagal nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: a phase IIa, sham controlled randomised trial.
Detailed Description
Loss of autonomic variability is strongly associated with adverse outcomes after ischaemic stroke. Removing blood clots from the brain by mechanical thrombectomy has revolutionised the management of s...
Eligibility Criteria
Inclusion
- Undergoing mechanical thrombectomy for acute ischaemic stroke requiring general or sedation.
- Established hypertensive and/or hypertensive on admission for mechanical thrombectomy \[systolic BP \>140mmHg; diastolic BP \>80mmHg\]
Exclusion
- Current participation in a clinical trial of a treatment with a similar biological mechanism.
- Previous enrolment into VANS trial.
- Anatomical or other contraindication to trans-cutaneous auricular sensory stimulation
- Pregnancy.
Key Trial Info
Start Date :
April 26 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 21 2023
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT05417009
Start Date
April 26 2023
End Date
July 21 2023
Last Update
July 14 2025
Active Locations (1)
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1
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
London, United Kingdom, EC1M 6BQ