Status:
COMPLETED
Serum and Saliva Sirtuin 6, Lipoxin A4, Caspase8 Levels in Correlation With Periodontal Status in Severe Periodontitis
Lead Sponsor:
Istanbul Medipol University Hospital
Conditions:
Periodontitis
Diagnose Disease
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
It has been stated that Sirtuin-6 (SIRT6) play a important role in regulation of inflammation, energy metabolism, homeostasis and apoptosis, and SIRT6 may be assosiciated with many diseases. The aim o...
Detailed Description
20 patients with Stage III Grade B periodontitis (P) and 20 periodontally healthy individuals (control;C) were included in this study. Clinical periodontal parameters were measured. Saliva and serum l...
Eligibility Criteria
Inclusion
- systemically healthy
- clinical diagnosis of periodontitis
- clinical diagnosis of periodontal health
Exclusion
- history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)
- nonsurgical periodontal treatment (previous 6 months)
- surgical periodontal treatment (previous 12 months)
- presence of\<10 teeth
- current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)
- diabetes
- diagnosis of rheumatoid arthritis
- pregnancy
- lactating
- smoking
- excessive alcohol consumption.
Key Trial Info
Start Date :
October 14 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05417061
Start Date
October 14 2021
End Date
May 30 2022
Last Update
October 23 2023
Active Locations (1)
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1
Istanbul Medipol University, School of Dentistry
Istanbul, Fatih, Turkey (Türkiye), 34083