Status:
COMPLETED
Akkermansia and Weight Maintenance
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Obesity
Microtia
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
Obesity and related disorders such as type 2 diabetes are a worldwide diet-related problem. As such new treatment options are constantly being developed. Bacteria living in the gut seem to be a key pl...
Detailed Description
RATIONALE This study will examine the influence of specific beneficial gut bacteria in relation to weight maintenance. The worldwide prevalence of obesity, obesity-associated insulin resistance, and t...
Eligibility Criteria
Inclusion
- BMI ≥ 28 kg/m2 \< 40 kg/m2
- Weight stable for at least 3 months (± 2 kg).
Exclusion
- Type 2 diabetes mellitus (fasting plasma glucose ≥ 7.0 mmol/L)
- Gastroenterological diseases
- Surgery on the gastrointestinal tract (ex.Bariatric surgery)
- Cardiovascular diseases, cancer, liver or kidney malfunction, a disease with a life expectancy of \< 5 years;
- Alcohol (\>15 standard drinks per week) or drug abuse
- Excessive nicotine use is defined as \>20 cigarettes per day;
- Use of prebiotics or probiotics 3 months prior to the start of the study;
- Intensive exercise training, \> 3 hours a week;
- Use of any medication influencing glucose or fat metabolism (ex. lipid-lowering-drugs e.g. PPAR γ (peroxisome proliferator-activated receptors) or PPARα (fibrates) agonists), glucose-lowering agents (including all sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide, and insulin), inflammation (e.g. anti-inflammatory or immunosuppressive drugs) and anti-oxidants);
- Regular use of laxatives
- Use of antibiotics in the last 3 months
- Vegan
- Lactose intolerance
- Pregnancy or lactation
- Concomitant participation in another study
Key Trial Info
Start Date :
July 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2023
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05417360
Start Date
July 22 2022
End Date
November 20 2023
Last Update
November 27 2023
Active Locations (1)
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1
Department of Human Biology, Maastricht University Medical Centre
Maastricht, Limburg, Netherlands, 6200MD