Status:
ACTIVE_NOT_RECRUITING
Using the Blood Eosinophil Count to Guide Systemic Corticosteroid Treatment in Asthma Exacerbations
Lead Sponsor:
Changi General Hospital
Collaborating Sponsors:
Singapore General Hospital
Conditions:
Asthma Attack
Asthma
Eligibility:
All Genders
21+ years
Phase:
PHASE2
Brief Summary
Asthma attacks which are moderate-to-severe are typically treated with corticosteroids, but the optimal treatment duration is unknown and treatment responses can be variable. Inadequate treatment may ...
Eligibility Criteria
Inclusion
- Age ≥ 21 years old
- Admitted for acute exacerbation of asthma and have received ≤ 3 days of systemic corticosteroids
- Have a had a blood eosinophil count (as part of routine clinical care) drawn before administration of systemic corticosteroid
- Have not taken SCS within 7 days prior to presentation to hospital
Exclusion
- Concomitant pneumonia
- Admission to high-dependency/intensive care unit, or requirement for invasive/noninvasive mechanical ventilation
- Eosinophilia due to other known causes (eosinophilic granulomatosis and polyangiitis, parasitic infections, malignancy)
- Other concomitant respiratory conditions e.g. chronic obstructive pulmonary disease, bronchiectasis
- Those on anti-IL5 or anti-IL5R treatment
- Pregnant subjects
- Subjects who are already on an investigational drug or has been participating in another clinical study with an investigational product within the last 6 months
- Subjects deemed by investigators to have a life expectancy of \< 12 months (any cause)
- Prisoners
Key Trial Info
Start Date :
June 2 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT05417906
Start Date
June 2 2022
End Date
September 30 2026
Last Update
August 21 2024
Active Locations (2)
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1
Singapore General Hospital
Singapore, Singapore, 168753
2
Changi General Hospital
Singapore, Singapore, 529889