Status:
COMPLETED
Role of Monocytes Sub-populations in Thrombosis Associated With Myeloproliferative Neoplasms (MonSThr)
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Myeloproliferative Neoplasm
Eligibility:
All Genders
18+ years
Brief Summary
Myeloproliferative neoplasms (MPN) are hematological malignancies associated with a major risk of thrombosis. Monocytes are hematopoietic cells with a central role in thrombosis. An activation of mono...
Detailed Description
Myeloproliferative Neoplasms (MPN) are hematological malignancies characterized by an increased risk of thrombosis, in particular in Polycythemia Vera (PV) and Essential Thrombocythemia (ET). Predicti...
Eligibility Criteria
Inclusion
- Adults patients (age ≥ 18 years)
- Inclusion at diagnosis or during the year following the diagnosis of PV or ET (2016 WHO criteria except bone marrow biopsy that is optional in the presence of a marker of clonality)
- Subject registered with a social security scheme
- Written informed consent obtained
Exclusion
- Patients with cytoreductive treatment (hydroxyurea, anagrelide, interferon, ruxolitinib) at the time of blood sampling
- Chronic inflammatory disease (cancer, vasculitis, rheumatism, hepato-gastro-intestinal diseases).
- Long term anti-inflammatory treatments:
- Corticoids
- Nonsteroidal anti-inflammatory drugs
- Aspirin (\> 325 mg per day)
- Cyclo-oxygenase II inhibitors
- Persons under judicial safeguards, trustee or curatorship
- Person unable to give her consent
- Non-cooperative person
- Exclusion period after another clinical study or participation to another clinical study in the 30 days before inclusion
Key Trial Info
Start Date :
October 5 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 22 2025
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT05419648
Start Date
October 5 2022
End Date
July 22 2025
Last Update
July 30 2025
Active Locations (5)
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1
CHU de Bordeaux, Hématologie clinique et thérapie cellulaire
Bordeaux, France
2
CHU de Bordeaux, Laboratoire Hématologie
Bordeaux, France
3
CHU de Bordeaux, Médecine interne et immunologie clinique
Bordeaux, France
4
CHU de Bordeaux, Médecine Interne et maladies infectieuses
Bordeaux, France