Status:
COMPLETED
Sleep, Hypertension, and Nocturia: a Multicomponent Approach for Comorbid Illnesses
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Nocturia
Hypertension
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
In this study the investigators target three common and comorbid illnesses among older adults namely nocturia or waking at night to void, poor sleep and hypertension. The aim of this proposal is to te...
Detailed Description
The investigators posit that a vicious cycle operates between nocturia, poor sleep, and nighttime hypertension (HTN). HTN act through the pressure-natriuresis mechanism that links sodium (Na) and BP h...
Eligibility Criteria
Inclusion
- The study shall include: ambulatory and functionally-independent community-dwelling men and women aged 65+ years, with
- nocturia ≥2/night, and
- history of high blood pressure and receives one or more non-diuretic, once daily antihypertensive- angiotensin converting enzyme inhibitor (ACE-I), angiotensin receptor blocker (ARB), calcium channel blocker (CCB), beta blocker
Exclusion
- Unstable or acute medical or central nervous system conditions
- Untreated, current, severe psychiatric condition
- Untreated, current, severe overactive bladder syndrome
- Post void residual \> 30ml
- Montreal cognitive assessment (MOCA) \<26
- Currently diagnosed and/or treated Obstructive Sleep Apnea, Restless Legs Syndrome, parasomnia
- Congestive heart failure, by exam
- Chronic kidney disease, stage III-V (eGFR\<60)
- \>14 alcohol drinks per week
- \>3 caffeinated drinks (\~300mg) per day
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05419830
Start Date
June 1 2022
End Date
January 30 2024
Last Update
December 17 2024
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213