Status:
COMPLETED
Prebiotic and Anti-inflammatory Effects of a Pectin Polysaccharide
Lead Sponsor:
Örebro University, Sweden
Collaborating Sponsors:
NutriLeads B.V. (Wageningen, The Netherlands)
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of this study is to determine, quantify and understand the potential prebiotic and anti-inflammatory effects of the pecticpolysaccharide rhamnogalacturonan I (RG-I). The effects of these dieta...
Detailed Description
The dietary fibre fractions from RG-I will be tested first for their prebiotic potential. Batch culture fermentation systems containing basal growth medium will be inoculated with faecal homogenates o...
Eligibility Criteria
Inclusion
- Signed consent prior to any study related procedures
- Age 18-65 years
- Willing to abstain from regular consumption of prebiotics/probiotics products or medication known to alter gastrointestinal functions at least 4 weeks prior to the study visits
Exclusion
- Previous complicated gastrointestinal surgery
- Presence of gastrointestinal disorder or any disorder which the principal investigator considers to affect the results of the study
- Current diagnosis of psychiatric disease
- Current and past diagnosis inflammatory gastrointestinal disease (e.g. Irritable Bowel Disease)
- Systemic use of antibiotics or steroids medications in the last 3 months
- Frequent use of NSAID (Non Steroidal Anti Inflammatory Drugs) the last 2 months prior to study visits
- Regular consumption of prebiotic/probiotic products for the past 4 weeks
- Abuse of alcohol or drugs
- Frequent use of laxatives, anti-diarrheal, anti-cholinergic within last 12 weeks prior to study visits
- Pregnancy and breast-feeding
Key Trial Info
Start Date :
June 6 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2023
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT05421793
Start Date
June 6 2022
End Date
August 30 2023
Last Update
September 21 2023
Active Locations (1)
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1
Campus USÖ
Örebro, Sweden, 703 62