Status:
RECRUITING
Neural Connectivity During Therapy for Adolescent PTSD
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
PTSD
Adolescent
Eligibility:
All Genders
12-17 years
Phase:
NA
Brief Summary
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of t...
Detailed Description
Posttraumatic stress disorder (PTSD) during adolescence negatively impacts brain networks underlying cognitive, social, and emotional function. Early intervention is important for mitigating long-term...
Eligibility Criteria
Inclusion
- ages 12-17 and Tanner stage 2 or above
- history of interpersonal trauma
- PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month
Exclusion
- current or past use of psychiatric medications
- severe suicidal/homicidal ideation
- current hospitalization
- other current psychotherapy or previous treatment with TF-CBT
- history of head injury with loss of consciousness for \>5 minutes
- IQ\<85
- major medical illness
- MRI contraindications (metal in body; braces on teeth)
- psychosis, bipolar 1, autism, developmental disorder, panic disorder
- first-degree family member with diagnosis of psychosis or bipolar I disorder
- substance dependence within the past 3 months or current drug use that is frequent
Key Trial Info
Start Date :
November 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2027
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT05423444
Start Date
November 29 2022
End Date
February 28 2027
Last Update
January 3 2025
Active Locations (1)
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1
UT Health Department of Psychiatry
San Antonio, Texas, United States, 78229