Status:
COMPLETED
AAT + tDCS to Reduce Cue-induced Craving and Smoking Behavior
Lead Sponsor:
Cynthia Conklin
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Smoking Behaviors
Smoking, Cigarette
Eligibility:
All Genders
26-55 years
Phase:
NA
Brief Summary
Smokers are highly reactive to smoking-related stimuli and report that this cue reactivity (CR) is a major obstacle to quitting. To date, no pharmacologic methods attenuate CR, and attempts to diminis...
Detailed Description
Exposure to smoking-related cues robustly increases self-report craving and immediate subsequent smoking. This cue-reactivity (CR) is an often-reported obstacle to quitting among smokers. Unlike metho...
Eligibility Criteria
Inclusion
- Between the ages of 26 \& 55
- High treatment interest (planning to quit within the next 6 months)
- Ability to provide written informed consent
- Smoke equal or greater than 7 cigarettes per day
- Expired breath carbon monoxide (CO) equal or greater than 8 ppm at screening
- Ability to attend 10 sessions over a 3-week period, and complete 2 follow-up phone assessments
Exclusion
- Epilepsy or Current Seizure Disorder
- Alcohol or Substance Dependence past 3 months (caffeine allowed, nicotine is part of inclusion criteria, alcohol \> 14 drinks per week (M) or \> 7 drinks per week (F))
- Implanted cardiac or brain medical devices
- History of epilepsy or current seizure disorder
- History of brain surgery or skull fracture
- History of a head trauma (losing consciousness \>10 min and/or problems with speech or movement because of head injury)
- Latex allergy
- Scalp irritation
- History of diabetes that caused loss of consciousness (\>10 min) or weakness in your arms or legs
- History of electroconvulsive therapy (ECT) in the last 5 years (Y / N) History of ECT within the last 5 years
- Current use of dextromethorphan
- Diagnosed with or undergone treatment for alcohol or substance dependence past 3 months
- Uncorrected vision deficit
- Colorblindness
- Use of tobacco products other than commercially available cigarettes
Key Trial Info
Start Date :
April 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 14 2024
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT05426460
Start Date
April 29 2022
End Date
June 14 2024
Last Update
July 10 2025
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213