Status:

COMPLETED

Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients

Lead Sponsor:

Saiful Anwar Hospital

Conditions:

Systemic Lupus Erythematosus

Eligibility:

FEMALE

18-45 years

Phase:

PHASE2

Brief Summary

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with a relatively high mortality and morbidity rate, especially in developing countries such as Indonesia. In Indonesia, a p...

Detailed Description

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with a relatively high mortality and morbidity rate, especially in developing countries such as Indonesia. In Indonesia, a p...

Eligibility Criteria

Inclusion

  • SLE patients referred to the Rheumatology outpatient clinic Saiful Anwar General Hospital, Malang, Indonesia
  • Had an active disease, characterized by the Mexican SLE Disease Activity Index (Mex-SLEDAI) score \>3
  • Had low vitamin D levels (serum vitamin D3 levels \<30 ng/ml)

Exclusion

  • Pregnant or breast-feeding patients
  • Took supplementations containing vitamin D or curcumin in the last three months
  • Had severe liver disorders (AST or ALT levels \>2.5 times of upper normal limit)
  • Had impaired renal function (GFR \< 25 ml/min or oliguria with urine output \< 400 ml/day)
  • Had other autoimmune diseases or severe infections such as tuberculosis, pneumonia, or HIV, history of renal stones, hypercalciuria, intestinal malabsorption
  • Refusal to participate in the study

Key Trial Info

Start Date :

March 1 2020

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

January 31 2022

Estimated Enrollment :

45 Patients enrolled

Trial Details

Trial ID

NCT05430087

Start Date

March 1 2020

End Date

January 31 2022

Last Update

June 24 2022

Active Locations (1)

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Page 1 of 1 (1 locations)

1

Saiful Anwar General Hospital

Malang, East Java, Indonesia, 65112

Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients | DecenTrialz