Status:
COMPLETED
Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency
Lead Sponsor:
American University of Beirut Medical Center
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
Conditions:
Nicotine Vaping
Nicotine Dependence
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Electronic nicotine delivery systems (ENDS) heat and vaporize a nicotine-containing liquid to produce an aerosol that can deliver nicotine to the blood and the brain. ENDS use has increased rapidly in...
Detailed Description
Assess the influence of nicotine flux and nicotine form on subjective effects. At AUB, the investigators will assess subjective effects (e.g. product liking, nicotine craving) and puffing topography f...
Eligibility Criteria
Inclusion
- Must be healthy and above 18 years of age
- Must be willing to provide informed consent, attend the lab, and abstain from tobacco/nicotine as required (participants will be instructed to abstain from nicotine/tobacco and/or ENDS use for ≥12h)
- A dual ENDS and tobacco user who reports daily use of ENDS (≥ 3 mg/ml nicotine) or cigarettes (any frequency) AND someday use (≥ 3 days/week) of ENDS (≥ 3 mg/ml nicotine) or cigarettes (any frequency) for the past 3 months or longer
Exclusion
- History of chronic disease or an uncontrolled psychiatric condition
- History of or active cardiovascular disease, low/high blood pressure, seizures, regular use of a prescription medication (except vitamins/birth control)
- Past month use of cocaine, opioids, benzodiazepines, or methamphetamines
- Individuals who report using marijuana \>15/30 days
- Women will be excluded if they are breast-feeding or pregnant
- Participants intending to quit tobacco/nicotine use in the next 30 days and referred to cessation treatment
Key Trial Info
Start Date :
July 13 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 11 2025
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT05430334
Start Date
July 13 2022
End Date
July 11 2025
Last Update
July 17 2025
Active Locations (1)
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1
American University of Beirut
Beirut, Lebanon, 11-0236