Status:
COMPLETED
Feasibility of Slow Continuous UltraFiltration For Deresuscitation in Critically Ill Patients
Lead Sponsor:
Belfast Health and Social Care Trust
Conditions:
Fluid Overload
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To determine the feasibility and safety of deresuscitation using slow continuous ultrafiltration with regional citrate anticoagulation and peripheral or standard central venous access.
Detailed Description
Fluid deresuscitation has been shown to have favourable outcomes in the management of the critically ill patient. Whilst diuretic medications have previously been the mainstay of achieving this deresu...
Eligibility Criteria
Inclusion
- Adults (\>18 years)
- Evidence of fluid overload (greater than trace amount of peripheral oedema in \>1 site, pulmonary oedema on chest radiograph, or positive fluid balance equivalent to \>5% body weight)
- Clinician intention to target a negative fluid balance
- Expected to remain in a critical care setting beyond the next calendar day
Exclusion
- Anticipated unavailability of suitable vascular access
- Lack of commitment to full support
- Receiving or imminently planned to receive renal replacement therapy
- Hyponatraemia (Sodium \<130mmol/L)
- Hypernatraemia (Sodium \>150mmol/L)
- Significant metabolic alkalosis (Bicarbonate\>30 and pH\>7.5)
- Significant metabolic acidosis (HCO3- \<18 mmol/l and pH \< 7.30)
- Uncorrected hypokalaemia (Potassium \<3.0mmol/L)
- Liver failure (Child-Pugh Grade B or above)
- Shock (any of: lactate \>3mmol/L, extensive skin mottling, central capillary refill time\>3 seconds, more than 1 vasoactive agent in use, noradrenaline dose \>0.2 mcg/kg/min, use of dobutamine, adrenaline, milrinone, enoximone or levosimendan)
- Receiving any systemic anticoagulation other than for routine venous thromboembolism prophylaxis, or dual antiplatelet therapy
- Prisoner
- Known pregnancy
Key Trial Info
Start Date :
August 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2024
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT05431491
Start Date
August 12 2022
End Date
December 1 2024
Last Update
May 2 2025
Active Locations (1)
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1
Belfast City Hospital
Belfast, Down, United Kingdom, BT97AB