Status:
COMPLETED
64Cu-DOTATATE PET-CT-skanning and Infective Endocarditis.
Lead Sponsor:
Emil Loldrup Fosbol
Conditions:
Endocarditis
Endocarditis;Chronic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigators hypothesize that the 64Cu-DOTATATE will show uptake in the infected vegetations on the prosthetic heart valves and increase the accuracy of the right diagnosis - thus increasing the ...
Detailed Description
Infective endocarditis (IE) is an infection of the heart lining, primarily mediated by an endothelial injury causing activation of inflammatory cytokines and cells thus forming a thrombus creating a b...
Eligibility Criteria
Inclusion
- Age ≥ 18 years old
- Be able to understand given information and sign informered consent
- Group A: native heart valves without clinical or paraclinical sign of infection
- Group B: native heart valves with verified endocarditis (according to modified Duke-criteria)
- Group C: prothethic heart valves(mechanical or biological) without clinical or paraclinical sign of infection and more \>1 year sind the heart operation
- Group D: infected prothethic heart valves, in addition clinical and paraclinical signs of infection (blood cultures and samples) and echocardiography
- Group E: newly operated in the heart valves without infection (6 months since operation)
- Group F: newly heart valve operation due to endocarditis (6 monts since operation)
- Group G: chronical infection in the aortic valce - lifelong antibiotics.
Exclusion
- allergi for 64Cu-DOTATATE or 18-FDG
- obesity(weight over 140 kg)
- critically ill, and PET scan not possible
- Pregnancy or suspected pregnancy - negativ hCG will be required for fertile women
- severe claustrophobia
- diabetes - defined by farmacological treatment
- recent heart operation(\<4 weeks)
Key Trial Info
Start Date :
April 28 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 29 2023
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT05432427
Start Date
April 28 2022
End Date
September 29 2023
Last Update
December 27 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Rigshospitalet
Copenhagen, Capital Region, Denmark, 2100