Status:
ACTIVE_NOT_RECRUITING
MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta
Lead Sponsor:
University Hospital, Angers
Collaborating Sponsors:
Fondation de l'Avenir
Conditions:
Aortic Aneurysm and Dissection
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The main objective is to compare the mitochondrial dynamic between patients operated for aneurysm of ascending aorta or type A aortic dissection (AAD) or control group
Detailed Description
In an aortic aneurysm process, the alteration of the extracellular matrix (ECM) as well as the apoptosis of the smooth muscle cells are due to inflammatory phenomena and oxydative stress, involving mi...
Eligibility Criteria
Inclusion
- Aneurysm aortic group: patients treated for an aneurysm of the ascending thoracic aorta with surgical indication according to the ESC guidelines (2014).
- Aortic dissection group: patients treated for type A acute aortic dissection or intramural hematoma of the ascending thoracic aorta in emergency.
- Control group: patients operated for aortic valve replacement (little aortic sample before closing aortotomy) or coronary artery bypass grafting which the use of a saphenous graft and the performance of a proximal anastomosis on the ascending aorta is planned
Exclusion
- Patients under 18 years old
- Other acute aortic syndromes (penetrating ulcers, iatrogenic or traumatic dissections)
- Patients treated for aortic valve replacement in the context of infective endocarditis
- Patients treated for emergency aortic valve replacement or coronary bypass surgery\*\*
- Pregnant, parturient and breastfeeding women
- Patients protected by an administrative or judicial measure (curatorship, guardianship)
- Patients receiving psychiatric care under duress
- Adults subject to a legal protection measure.
- Patients whose the samples planned for the study could not be taken;
- Patients in the control group whose tissue sampling will not be performed.
Key Trial Info
Start Date :
September 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 23 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05434481
Start Date
September 7 2022
End Date
October 23 2024
Last Update
June 11 2024
Active Locations (1)
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1
Olivier FOUQUET
Angers, France