Status:
UNKNOWN
Blood Pressure and Cerebral Blood Flow After Cardiac Arrest
Lead Sponsor:
Niels Damkjær Olesen
Conditions:
Out-Of-Hospital Cardiac Arrest
Post-Cardiac Arrest Syndrome
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Comatose patients that are admitted to an intensive care unit after out-of-hospital cardiac arrest (OCHA) have a high mortality, particularly due to hypoxic-ischemic neurologic injury. These patients ...
Detailed Description
Background Patients suffering out-of-hospital cardiac arrest (OCHA) have poor prognosis, and of the patients admitted to a hospital after return of spontaneous circulation, the 1 year survival is appr...
Eligibility Criteria
Inclusion
- Patients who are resuscitated within the last 48 hours after OCHA due to suspected or confirmed cardiac cause.
- Comatose or sedated (Glasgow Coma Score \< 8 whereby the patient is unable to follow verbal commands).
- Age 18-90 years.
Exclusion
- Patients that have had in-hospital cardiac arrest.
- Pregnancy, human chorionic gonadotropin is routinely measured in women \< 60 years of age.
- Known hemorrhagic diathesis (medically induced coagulopathy due to blood thinners is not an exclusion criteria, except for those mentioned below).
- Anticoagulant therapy by warfarin with an INR \> 2, Direct-Acting Oral Anticoagulants, or Eptifibatid.
- Suspected or confirmed stroke.
- Non-witnessed cardiac arrest with asystole as the initial rhythm.
- Known treatment limitation plan or a decision not to resuscitate the patient in case of a new cardiac arrest.
- Previous disease that makes 180 day survival unlikely.
- Known Cerebral Performance Category score 3 to 4 prior to cardiac arrest.
- Systolic blood pressure \< 80 mmHg despite optimal fluid-, vasopressor-, and inotropic treatment.
- The need of noradrenaline infusion exceeding 0.3 μg/kg\*min in order to maintain a MAP of 65 mmHg.
- Mechanical cardiac support devices.
- Known vascular disease in the internal carotid artery.
- Lack of visualization of the internal carotid artery, e.g. due to high placement of the bifurcation.
Key Trial Info
Start Date :
September 9 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05434910
Start Date
September 9 2022
End Date
January 30 2024
Last Update
September 13 2022
Active Locations (1)
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1
Rigshospitalet
Copenhagen, Denmark, 2100