Status:
UNKNOWN
Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis
Lead Sponsor:
Cairo University
Conditions:
Periodontitis Stage I
Periodontal Diseases
Eligibility:
All Genders
18-70 years
Phase:
EARLY_PHASE1
Brief Summary
this study addresses the effect of the vitamin B3 and vitamin B9 on the periodontal healing at the sites of periodontal destruction due to periodontitis and evaluate its added effect to the convention...
Detailed Description
This study is a parallel group randomized, Double-blinded, Placebo-controlled clinical trial The follow up of this study is set to be in a three months interval in order to monitor the effect of the p...
Eligibility Criteria
Inclusion
- patients with gingivitis or stage I/II periodontits. The presence of gingivitis and the presence/severity of periodontitis is registered using the American Academy of Periodontology 2017 workshop published definition With this method, patient was identified affected by periodontits when ''Interdental CAL is detectable at ≥2 non-adjacent teeth, or Buccal/oral CAL ≥3 mm with pocketing \>3 mm is detectable at ≥2 teeth'' (Toentti et al, 2018) with grade I severity being cases with interdental CAL from 1-2mm and grade II severity being cases with interdental CAL from 3-4 mm
Exclusion
- Patients incapable of giving informed consent
- Patients unable to attend the 3-month follow-up
- Patients with interdental CAL \>4mm
- Patient requiring surgical periodontal treatment
- Patients on systemically administered vitamin B or vitamin B-complex
- Patients undergoing chemo- or immunosuppressive therapy over the previous 5 years
- Patients treated or undergoing treatment with intravenous amino-bisphosphonates
- Patients with poor oral motivation
- Substance abusers
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05435378
Start Date
July 1 2022
End Date
December 1 2022
Last Update
June 28 2022
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