Status:
UNKNOWN
Neurochemical Mechanisms of the Awake vs. Anesthetized Brain
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Boston University
Conditions:
Anesthesia
Healthy
Eligibility:
All Genders
18-45 years
Phase:
EARLY_PHASE1
Brief Summary
The investigators will be studying the sedative drug dexmedetomidine using hybrid PET/fMRI/EEG imaging to better understand the neuropharmacology of anesthesia/artificially induced sleep.
Detailed Description
A group of healthy volunteers will undergo simultaneous PET/fMRI/EEG imaging under two different conditions: while being administered a sedative (dexmedetomidine), and while being administered a norma...
Eligibility Criteria
Inclusion
- Adults aged 18-45.
- No contraindications to MRI or PET scanning.
Exclusion
- Contraindications to fMRI scanning and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia);
- Pregnancy or breast feeding;
- Current or past history of major medical, neurological, or psychiatric condition;
- History of major head trauma;
- Any cardiovascular disorders, including heart disorders or high blood pressure \[\>155/95\];
- Breathing problems such as severe asthma;
- Bleeding disorder, or use of anticoagulants;
- Bladder obstruction, urinary problems, or history of impaired elimination;
- Known kidney or liver problems;
- Intestinal blockage;
- Raynaud syndrome
- Peripheral nerve injury;
- Diabetes;
- Glaucoma;
- Sleep disorder, such as sleep apnea, insomnia, or narcolepsy
- Current use of any drugs that affect sleep
- Current or recent use of medications (neurological or psychiatric) affecting brain function
- Current or past history of chronic pain (assessed at discretion of PI);
- History of allergic reactions
- History of chronic obstructive pulmonary diseases
- Ulcerative skin conditions or other dermatologic conditions which could interfere with blood pressure cuff placement
- Body mass index above 30
- Current smoker
- Lack of current health insurance coverage
- Employed under the direct supervision of the investigators conducting the research
- Hair in dreadlocks, twists, or braids that cannot be removed
- Eczema on the scalp or face
Key Trial Info
Start Date :
April 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05435560
Start Date
April 12 2022
End Date
April 1 2023
Last Update
June 28 2022
Active Locations (1)
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1
Athinoula A. Martinos Center for Biomedical Imaging
Charlestown, Massachusetts, United States, 02129