Status:
COMPLETED
Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Virginia Polytechnic Institute and State University
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Cerebellar Ataxia
Spinocerebellar Ataxias
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The aim of the research is to improve motor function in people with cerebellar ataxia by using neuroimaging methods and mental imagery to "exercise" motor networks in the brain. The relevance of this ...
Eligibility Criteria
Inclusion
- 18-100 years of age
- At least 8th-grade education
- Right-handedness
- Clinical diagnosis of progressive, degenerative cerebellar ataxia by a movement disorder specialist (cerebellar ataxia of unknown etiology, and spinocerebellar ataxias with and without genetic confirmation)
Exclusion
- History of Axis I psychiatric disorders (including alcohol and drug dependence)
- Severe or unstable medical disorder, neurological disorders, such as stroke or epilepsy
- History of head injury that resulted in a loss of consciousness greater than 5 minutes and/or neurological sequelae
- Any condition that is contraindicated for the MRI environment (e.g., metal in the body, pacemaker, claustrophobia)
- Currently pregnant
- Clinical diagnosis of multiple system atrophy (MSA) or Friedrich's ataxia (FA)
- Eligible subjects may be asked to refrain from medications that affect the central nervous system that would also make data difficult to interpret (e.g., sedatives) for an appropriate period of time prior to scanning
- Participants will be excluded if the participants do not have a home computer with internet available to complete the 3-week at-home component of the study protocol
Key Trial Info
Start Date :
March 14 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 22 2024
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT05436262
Start Date
March 14 2023
End Date
January 22 2024
Last Update
January 8 2025
Active Locations (1)
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1
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21205