Status:
COMPLETED
Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
Lead Sponsor:
Erika Forbes
Conditions:
Depression
Eligibility:
All Genders
18-26 years
Phase:
NA
Brief Summary
The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect trai...
Detailed Description
The study has a longitudinal design in which participants complete a baseline assessment, 20 or 30 theta burst stimulation (TBS) sessions, a post-TBS assessment, and a follow-up assessment 4 months la...
Eligibility Criteria
Inclusion
- Current Diagnostic and Statistical Manual (DSM-5) Depressive Disorder
Exclusion
- Bipolar disorder (lifetime)
- Obsessive-compulsive disorder (lifetime)
- History of psychosis
- Daily use of nicotine
- Past-month use of cocaine, amphetamines, Methyl enedioxy methamphetamine (MDMA), Phencyclidine (PCP), Ketamine, or gamma-hydroxybutyrate (GHB)
- Past 6 month substance use disorder
- Binge drinking (using NIAAA criteria) within the past week, alcohol use in the past 12 hours
- Neurological disorders: Epilepsy, Parkinson's Disease, brain tumor, brain injury, stroke
- History of head trauma with a loss of consciousness (e.g., concussion)
- History of seizures
- MRI contraindications: body shape/size too large to fit in scanner, claustrophobia, and ferromagnetic metal in the body
- Pregnancy
- Current use of Clozapine, Bupropion, or prescription stimulants
- Current use of benzodiazepines or mood stabilizers
- Body shape/size too large to fit in MRI scanner
- Claustrophobia
- Metal in the head or ferromagnetic metal in the rest of the body
- Implanted medical devices
- High-risk suicidality
Key Trial Info
Start Date :
June 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2025
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT05436379
Start Date
June 17 2022
End Date
November 30 2025
Last Update
December 30 2025
Active Locations (1)
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1
The University of Pittsburgh, Department of Psychiatry
Pittsburgh, Pennsylvania, United States, 15213