Status:
RECRUITING
Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
Lead Sponsor:
Drexel University
Conditions:
Obesity
Overeating
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The changing food environment, with increasingly abundant ultra-processed food (UPF) options, may directly contribute to rising rates of obesity, though it is unknown which ingredients in UPF elevate ...
Detailed Description
The abundance of ultra-processed foods (UPFs) in our environment has led to excessive calorie intake and been cited as perpetuating the obesity epidemic. UPFs do not exist in nature and are created to...
Eligibility Criteria
Inclusion
- 18 to 65 years old
- BMI ≥ 30 kg/m2
- Endorse liking the test snack foods at a 6 on a 1-10 scale
- Live in the greater Philadelphia area and are willing/able to participate in six in-person assessments
- Can access and are willing/able to use a smartphone
- Able to give consent
Exclusion
- Unable to fluently speak, write, and read English
- BMI below 30 kg/m2
- Self-report dietary allergies or aversions to the test snack foods
- Current diagnosis of type 1 or 2 diabetes (HbA1c \> 6.5; will be confirmed by blood test at baseline) or self-reported diagnosis of hypertension
- Self-report a cardiovascular event (e.g., stroke, myocardial infarction) in the last 12 months
- Self-report current use of medications that may influence the metabolic responses of interest or inhibit appetite (e.g., metformin, liraglutide)
- Self-report a loss of ≥ 5% of their body weight in the last 6 months, as this may influence their food choices
- Self-report severe symptoms of mood (Beck Depression Inventory score ≥ 29), anxiety, and any severity of thought disorders
- Self-report severe binge eating disorder or full criteria bulimia nervosa
- Self-report active substance-use disorders
- Self-report current, active suicidal ideation, and/or a suicide attempt in the past year (will be referred to psychiatric treatment facilities in the greater Philadelphia area)
- Self-report a history of bariatric surgery
- Self-report current involvement in weight loss treatment or self-directed weight loss attempt
- Women who are nursing, pregnant, or planning to become pregnant in the next 3 months
- Does not have access or are not willing to use a smartphone
Key Trial Info
Start Date :
February 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05437809
Start Date
February 20 2023
End Date
March 31 2027
Last Update
May 6 2025
Active Locations (1)
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1
Drexel University
Philadelphia, Pennsylvania, United States, 19104