Status:
UNKNOWN
Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
Lead Sponsor:
Xuzhou Central Hospital
Collaborating Sponsors:
The Affiliated Hospital of Xuzhou Medical University
The First People's Hospital of Xuzhou
Conditions:
Postoperative Cognitive Dysfunction
Postoperative Delirium
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) occur in 11-51% of patients after surgery, and its prevalence increases with age. The occurrence of delirium is associated w...
Detailed Description
The investigators assessed POD by the Confusion Assessment Method for the ICU twice daily for 7 days after surgery. Participants' cognitive function was assessed with neuropsychological battery tests....
Eligibility Criteria
Inclusion
- 50 to 80 years old.
- ASA grade I-Ⅲ.
- elective knee or hip replacement.
Exclusion
- Mini-Mental State Examination (MMSE) score \< 23.
- Education years\<7.
- Peptic ulcer disease, serious cardiac-cerebral vascular disease.
- Neurological or psychiatric disorders.
- History of drug and alcohol abuse.
- Hepatic and/or kidney dysfunction.
- BMI\>35.
- Patients on antidepressants.
- ASA \>Ⅲ.
Key Trial Info
Start Date :
October 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2024
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT05439707
Start Date
October 1 2022
End Date
September 1 2024
Last Update
September 30 2022
Active Locations (1)
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1
Xuzhou Central Hospital
Changzhou, Jiangsu, China, 221009