Status:
UNKNOWN
Effects of Individualized Accurate Positioning TMS Based on Task fMRI Activation on Upper Extremity Function After Stroke
Lead Sponsor:
The First Affiliated Hospital with Nanjing Medical University
Conditions:
Stroke
Transcranial Magnetic Stimulation
Eligibility:
All Genders
35-80 years
Phase:
NA
Brief Summary
Stroke is a global health problem and a leading cause of disability. Limitation of upper limb function occurs in 55 -75% of patients after stroke. In recent years, non-invasive brain stimulation techn...
Eligibility Criteria
Inclusion
- patients with ischemic stroke;
- Primary onset, non-lateral motor area stroke lesion, duration of disease 15 days to 1 year;
- Hemiplegia with unilateral hemispheric injury;
- Brunnstrom grading (Brunnstrom, 1966)≤ STAGE IV;
- Unconscious disorder;
- Can cooperate to complete scale assessment, MRI scan and TMS treatment;
- Can complete manual tasks and obtain activation points in the lateral motor area of the healthy hemisphere;
- The head movement amplitude of all fMRI images was translational \< 2mm and rotational \< 2°;
- Consent to rTMS treatment on the basis of conventional treatment and pass TMS safety screening;
Exclusion
- Use of muscle relaxation drugs recently;
- A history of epilepsy;
- History of other neuropsychiatric diseases;
- Other motor system diseases;
- History of head trauma and serious heart disease;
- Contraindications to MRI scanning (implantable pacemaker, cardiac catheter or electronic pump; Intracerebral metal aneurysm clip, metal nail or vascular suture device; Intracerebral nerve stimulator or brain/subdural electrode, etc.)
- Skull defect was closed with metal plate at TMS stimulation site;
- Patients with skull defect;
- Other severe systemic diseases or clinical critical conditions (respiratory or hemodynamic instability);
- Refuse to participate in the trial.
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05440292
Start Date
July 1 2022
End Date
July 1 2024
Last Update
June 30 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210029