Status:
UNKNOWN
Walnut Consumption and Gut Microbiota
Lead Sponsor:
University of Illinois at Urbana-Champaign
Conditions:
Obesity
Inflammation
Eligibility:
All Genders
25-75 years
Phase:
NA
Brief Summary
Obesity is a growing health issue that effects the majority of adults in the United States. Prevalence of other metabolic diseases are increased in obese adults, including systemic inflammation. There...
Eligibility Criteria
Inclusion
- Participants will include adults ages 25-75 years BMI of \> 30 kg/m2 Ability to drop-off fecal sample within 15 minutes of defecation
Exclusion
- Walnut allergy or intolerance
- Food allergies or intolerances
- Prior diagnosis of metabolic or gastrointestinal disease (cardiovascular disease and type 1 or type 2 diabetes, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers, hepatitis, HIV, cancer, etc.)
- Women that are pregnant, had a baby within the last 12 months, or lactating
- Individuals that smoke, use tobacco, abuse drugs, or consume \> 2 alcoholic beverages per day.
- \> 5% weight change in the past month or \> 10% change in the past year
- Oral antibiotics during the previous 6 weeks
- Fasting blood glucose \>126 mg/dL, blood pressure \>160/100 mm Hg, elevation in serum transaminases (i.e. \>3 times the upper limit of normal) or with evidence of liver disease, including primary biliary cirrhosis or gallbladder disease, constipation, are currently taking lipid-lowering medications, oral hypoglycemic agents, or insulin, or certain medications (laxatives, bile acid sequestrants, and opiates)
- History of malabsorptive or restrictive bariatric surgeries (e.g., gastric bypass, sleeve gastrectomy, adjustable gastric band) or gall bladder removal surgery.
- Are unable to consume the experimental meals/snacks.
- Participants who have donated blood within the last 8 weeks
- Recent diagnosis of anemia
- Concurrent enrollment in another dietary, exercise, or medication study
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05441748
Start Date
June 1 2022
End Date
July 1 2024
Last Update
June 18 2023
Active Locations (1)
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1
Hannah Holscher
Urbana, Illinois, United States, 61801