Status:
RECRUITING
The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
Swiss National Science Foundation
Rising Tide Foundation
Conditions:
Lymphedema, Breast Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) ...
Detailed Description
To date, conservative complex physical decongestion therapy (CDT) is the gold standard for BCRL (breast cancer related lymphedema) and includes manual lymphatic drainage, local compression with bandag...
Eligibility Criteria
Inclusion
- Written informed consent.
- Patients ≥ 18 years of age.
- Former diagnosis of breast cancer.
- Clinical diagnosis of chronic Breast Cancer-Related Lymphedema (BCRL) (persisting for more than 3 months) classified as ≥ Stage 1, according to ISL.
- Minimum of 3 months Conservative Complex Physical Decongestion Therapy.
- Ability to complete the QoL questionnaires.
- Willingness to undergo surgery.
Exclusion
- No indication for lymphatic surgery according to clinical judgment of the treating surgeon (individual reasons will be specifically documented).
- Primary congenital Lymphedema or non-BCRL.
- Previous surgical BCRL treatment on the side intended for intervention.
Key Trial Info
Start Date :
July 14 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2036
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT05890677
Start Date
July 14 2023
End Date
June 1 2036
Last Update
November 14 2025
Active Locations (35)
Enter a location and click search to find clinical trials sorted by distance.
1
Yale School of Medicine
New Haven, Connecticut, United States, 06510
2
Harvard Medical School
Boston, Massachusetts, United States, 02115
3
Washington University School of Medicine in St. Louis
St Louis, Missouri, United States, 63110
4
Mayo Clinic
Rochester, New York, United States, 55905