Status:
RECRUITING
Exploration on the Value of MRD Based on ctDNA Detection in Predicting Recurrence of Resected Non-small Cell Lung Cancer
Lead Sponsor:
Shanghai Pulmonary Hospital, Shanghai, China
Conditions:
Non-small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Based on the unique patented MONOD and Methyl Titan methylation sequencing technology on lung cancer tissue and blood samples, a lung cancer MRD monitoring panel is designed. The panel is used to dete...
Eligibility Criteria
Inclusion
- Age ≥ 18 years old, regardless of gender;
- Patients with pathological diagnosis of non-small cell lung cancer and clinical staging of stage IB-IIIB;
- Able to undergo radical surgical treatment;
- Physical condition score (ECOG) ≤1;
- The expected survival time exceeds 24 months;
- Volunteer to participate in this study and sign an informed consent form.
Exclusion
- Individuals with a history of other malignant tumors within 5 years;
- Those who have undergone neoadjuvant therapy before surgery;
- Postoperative incision margin R1 or incision margin R2;
- Those who have undergone a blood transfusion within 2 weeks before the surgery;
- Individuals with systemic inflammatory response syndrome;
- Those with serious diseases of important organs such as the heart, lungs, kidneys, and brain;
- Participants in other clinical trials within the past 30 days and have taken investigational drugs;
- Due to various reasons, sampling cannot be completed, samples do not meet the requirements, or baseline samples (preoperative and postoperative plasma samples, tumor tissue samples) are incomplete;
- Researchers believe that it is not appropriate to participate in this experiment.
Key Trial Info
Start Date :
October 25 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2028
Estimated Enrollment :
377 Patients enrolled
Trial Details
Trial ID
NCT05965024
Start Date
October 25 2023
End Date
August 1 2028
Last Update
February 21 2024
Active Locations (1)
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1
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China, 200433