Status:
UNKNOWN
Calizumab Combined With Bevacizumab and Capecitabine in the Treatment of Head and Neck Squamous Cell Carcinoma
Lead Sponsor:
Second Affiliated Hospital of Guangzhou Medical University
Conditions:
Head and Neck Squamous Cell Carcinoma
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
This is a prospective, one-arm exploratory second-line study of carrilizumab combined with bevacizumab plus capecitabine in relapsed metastatic squamous cell carcinoma of the head and neck.
Detailed Description
This is a prospective, single-center, single-arm, phase II clinical study. The study was intended to include histologically or cytologically determined squamous cell carcinoma of the head and neck, wh...
Eligibility Criteria
Inclusion
- Histologically or cytologically determined, the investigators assessed patients with relapsed or metastatic squamous cell carcinoma of the head and neck. Including nasopharyngeal cancer, oral cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, etc.
- The age range is between 18 and 85.
- Expected survival \> 6 months.
Exclusion
- Patients with uncured malignancies other than recurrent or metastatic squamous cell carcinoma of the head and neck diagnosed within 5 years prior to initial administration (excluding radical cutaneous basal cell carcinoma, cutaneous squamous epithelial carcinoma, and/or carcinoma in situ after radical excision).
- Previous treatment with anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs or drugs that target another stimulus or synergistic inhibition of T cell receptors (e.g., CTLA-4, OX-40, CD137).
- Known allogeneic organ transplantation (except corneal transplantation) or allohematopoietic stem cell transplantation.
- other.
Key Trial Info
Start Date :
August 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2025
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT05965154
Start Date
August 1 2023
End Date
June 1 2025
Last Update
July 28 2023
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