Status:
UNKNOWN
Investigating LFP Correlates of TUS in Patients With Movement Disorders
Lead Sponsor:
University Health Network, Toronto
Conditions:
Parkinson Disease
Essential Tremor
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as sm...
Detailed Description
Experiment 1: Subjects will be randomly assigned to either the sham or active stimulation group during the first study visit. In the second study visit, there will be a crossover between the groups, w...
Eligibility Criteria
Inclusion
- Adult patients with movement disorders (diagnosed by a movement disorder specialist)
- Implantation of a Percept PC DBS system at least one month before the sonications
- Stable dopaminergic medication dose for a minimum of 4 weeks
Exclusion
- Concomitant neurological conditions (stroke, seizure, dementia, major depression / psychiatric disorders, active drug abuse/addiction and major neuromuscular/musculoskeletal diseases)
- Declined cognitive scores (MoCA score \< 22)
- Implants (cardiac pacemaker, implantable cardioverter-defibrillator, intracranial devices other than DBS system such as shunts and MR-unsafe devices)
- History of intracranial lesioning procedures
- Major systemic illness, infection or pregnancy
Key Trial Info
Start Date :
May 18 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT05965960
Start Date
May 18 2023
End Date
June 1 2024
Last Update
October 10 2023
Active Locations (1)
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1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8