Status:
UNKNOWN
Potential Benefits of Itopride in the Management of Patients With Metabolic Associated Fatty Liver Disease (MAFLD)
Lead Sponsor:
October 6 University
Collaborating Sponsors:
Beni-Suef University
Conditions:
Fatty Liver Disease
Fatty Liver
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
Objective of this study is to determine the clinical benefits of itopride in improvement of MAFLD
Detailed Description
the study will evaluate the possible benefits of itopride when added to pateints with metabolic associated fatty liver disease
Eligibility Criteria
Inclusion
- Patients presented to hepatology clinic . -Patients are diagnosed by ultrasonography and laboratory tests for liver and lipids. - -
- Patients with comorbidites like hypertension,diabetes,dyslipidemia
Exclusion
- Exclusion criteria included the presence of liver disease due to any of the following: viral hepatitis (HBV, HCV)
- acute systemic disease
- cystic fibrosis, coeliac disease
- suspicion of muscular dystrophy, alpha-1-antitrypsin deficiency
- metabolic inherited diseases
- autoimmune hepatitis, drug toxicity and drugs known to induce steatosis (e.g. valproate, amiodarone orprednisone).
- Patients were also excluded if body weight and carbohydrate metabolism were altered by the use of parenteral nutrition
- protein malnutrition
- previous gastrointestinal surgery
- structural abnormalitiesof the gastrointestinal tract or neurological impairment.
- the use of nonsteroidal anti-inflammatory drugs,antibiotics,sglt2,dpp4,statins,glp1
- probiotics or anti-secretory drugs capable of causing achlorhydria within 2 months preceding enrolmentwere also considered exclusion criteria.
- Patient with age below 18 or above 60
Key Trial Info
Start Date :
December 28 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05966025
Start Date
December 28 2023
End Date
December 1 2025
Last Update
October 31 2023
Active Locations (1)
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1
Maha Youssif Fekry
Giza, Egypt, 12573