Status:
UNKNOWN
Clinical Exploratory Research of Medial Prefrontal Cortex Combined With Dorsolateral Prefrontal Cortex Electrical Stimulation in the Treatment of Alzheimer's Disease
Lead Sponsor:
Xuanwu Hospital, Beijing
Conditions:
Alzheimer Disease
Electric Stimulation Therapy
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive cognitive impairment and memory impairment, and is also a major cause of global dementia, characterized by p...
Detailed Description
The main principle of DBS is to regulate the activity of neural components by implanting electrodes into key brain regions using a built-in pulse generator. The basic principle of using DBS in AD is t...
Eligibility Criteria
Inclusion
- Male or female aged 40 to 70;
- eets the diagnostic criteria for mild to moderate AD;
- A CDR score of 0.5 or 1.0;
- The MMSE score is between 18 and 28;
- Regularly taking cholinesterase inhibitors for more than 6 months
Exclusion
- Existence of brain structural abnormalities (such as brain tumors, cerebral infarction, and intracranial hematoma);
- Suffering from other neurological or psychiatric diseases;
- Accompanying comorbidities that are not suitable for surgical treatment;
- Individuals with contraindications for MRI or PET testing
Key Trial Info
Start Date :
July 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2025
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT05971030
Start Date
July 30 2023
End Date
July 30 2025
Last Update
August 2 2023
Active Locations (1)
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1
Xuanwu Hospital
Beijing, China