Status:
COMPLETED
The Safety and Efficacy of Alveolar Bone Defect Repair Induced by Gelatin Sponge-loaded Apoptotic Vesicle Complex
Lead Sponsor:
Fifth Affiliated Hospital of Guangzhou Medical University
Conditions:
Third Molar Extraction
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Distal bone loss of the second molar due to extraction of the third molar is one of the most common pathological conditions that results in tooth loss of second molar. However, regeneration of functio...
Detailed Description
This study is a single-center, prospective, two-arm study to evaluate the efficacy and safety of alveolar bone regeneration induced by gelatin sponge-loaded apoptotic vesicle complex in patients with ...
Eligibility Criteria
Inclusion
- Patients aged 18-45 (including the boundary value)
- Patients who need to extract the bilateral mandible third molars
- Patients who voluntarily sign the informed consent form
Exclusion
- The adjacent second molars in the patient's oral cavity are affected by pulp injury or insufficient endodontic treatment, or show tooth fracture, or have a degree of motion of 3 degrees
- The adjacent second molars have metal crowns or large amalgam restorations
- There is an uncontrollable pathological process in the patient's oral cavity
- Malnutrition (serum albumin concentration \<2 g/dl)
- Other systemic, infectious diseases and hereditary diseases, or patients in the acute inflammatory phase and acute exacerbation phase of chronic diseases
- Patients who are pregnant, lactating, or planning to become pregnant
Key Trial Info
Start Date :
August 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 30 2024
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT05971342
Start Date
August 20 2023
End Date
July 30 2024
Last Update
June 10 2025
Active Locations (1)
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1
The Fifth Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China, 510055