Status:
RECRUITING
Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis
Lead Sponsor:
Alice Ho Miu Ling Nethersole Hospital
Conditions:
Peritoneal Dialysis-associated Peritonitis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Biofilm formation is an important cause of catheter-related infection. In hemodialysis, use of an antibiotic-lock has been proven to be effective to manage such a complication with preservation of the...
Detailed Description
STUDY OBJECTIVES This study aims to evaluate whether the use of antibiotic-lock in the Tenckhoff catheter can eradicate the biofilm within the catheter lumen, thereby preventing further episodes of re...
Eligibility Criteria
Inclusion
- PD patients who suffer from Either relapsing peritonitis (within 4 weeks of completion of antibiotics) or repeat peritonitis (between 4 to 12 weeks of completion of antibiotics), in which the causative organism is confirmed to be identical to the one in the preceding peritonitis episode, or Persistent growth of bacteria from PD effluent (PDE) after completion of standard 2-week antibiotic treatment, despite the resolution of symptoms and PDE leukocyte count \<100/mm3
- Age \> 18 years old
- informed consent available
Exclusion
- Patients who do not respond to the appropriate IP antibiotics, evident by the persistence of peritonitis symptoms in which they should be referred for timely Tenchkoff catheter removal
- Fungal or mycobacterial PD peritonitis
- Co-existing exit site or tunnel tract infection
- The presence of Tenckhoff catheter drainage dysfunction
- \<= 3 years old
- Pregnant patients
Key Trial Info
Start Date :
June 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2026
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT05971537
Start Date
June 15 2023
End Date
October 1 2026
Last Update
January 31 2024
Active Locations (1)
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1
Alice Ho Miu Ling Nethersole Hospital
Tai Po, Hong Kong