Status:
COMPLETED
A Study of mRNA-1018 Pandemic Influenza Candidate Vaccines in Healthy Adults
Lead Sponsor:
ModernaTX, Inc.
Conditions:
Influenza
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this Phase 1/2 study is to generate sufficient safety and immunogenicity data of mRNA-1018 pandemic influenza candidate vaccines in healthy adults ≥18 years of age to enable the initiat...
Eligibility Criteria
Inclusion
- Key
- Healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and results of electrocardiogram testing.
- Body mass index of 18 kilograms (kg)/square meter (m\^2) to 39 kg/m\^2 (inclusive) at the Screening visit.
- For female participants of childbearing potential: negative pregnancy test, adequate contraception, and not currently breastfeeding.
- Key
Exclusion
- Participant is acutely ill or febrile (body temperature ≥ 38.0 degrees Celsius \[°C\]/100.4 degrees Fahrenheit \[°F\]) 72 hours prior to or at the Screening Visit or Day 1.
- History of a diagnosis or condition that, in the judgment of the Investigator, is clinically unstable or may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures.
- Any medical, psychiatric, or occupational condition, including reported history of substance abuse, that, in the opinion of the Investigator, might pose additional risk due to participation in the study or could interfere with the interpretation of study results.
- Participant has received systemic immunosuppressants or immune-modifying drugs for \>14 days in total within 180 days prior to Screening Visit (for corticosteroids ≥10 milligrams \[mg\]/day of prednisone equivalent) or is anticipating the need for immunosuppressive treatment at any time during participation in the study.
- Participant has received any vaccine authorized or approved by local health agency including mRNA vaccine ≤28 days prior to study intervention (Day 1) or plans to receive a vaccine authorized or approved by local health agency within 28 days before or after the study intervention.
- Participant has participated in an interventional clinical study within 28 days prior to the Screening visit based on the medical history interview or plans to do so while participating in this study.
- Other inclusion/exclusion criteria may apply.
Key Trial Info
Start Date :
July 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 16 2024
Estimated Enrollment :
1504 Patients enrolled
Trial Details
Trial ID
NCT05972174
Start Date
July 10 2023
End Date
July 16 2024
Last Update
July 16 2025
Active Locations (27)
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1
CenExel RCA
Hollywood, Florida, United States, 33024
2
Velocity Clinical Research
Savannah, Georgia, United States, 31406
3
Johnson County Clin-Trials
Lenexa, Kansas, United States, 66219
4
DM Clinical Research
Southfield, Michigan, United States, 48076