Status:
COMPLETED
Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center
Lead Sponsor:
Mansoura University
Conditions:
Renal Calculi
Eligibility:
All Genders
Brief Summary
Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based stones among Patients with Renal Calcular Disease in Mansoura Urology and Nephrology Center
Detailed Description
Back ground: Nephrolithiasis is a prevalent disease with high morbidity, the incidence and prevalence of nephrolithiasis has risen worldwide. Calcium nephrolithiasis may be considered as a complex dis...
Eligibility Criteria
Inclusion
- All patients with unilateral or bilateral renal stones (de novo or recurrent) who were candidates for endoscopic or surgical intervention were included. Metabolic workup was done for selected patients with radio-opaque stones, while genetic testing was done for those with dominant Ca composition proven by postoperative stone analysis. Thirty healthy individuals with no urologic abnormalities were involved as control cases. Patients with renal calculi for whom metabolic and genetic testing were performed are designated "α" cases.
Exclusion
- For metabolic and genetic testing, patients with a well-known lesion precipitating stone disease were excluded e.g. ureteric stricture, ureteropelvic or ureterovesical junction obstruction, urinary diversion, history of ureterovesical re-implantation as well as patients with non-Ca stones by post-operative stone analysis
Key Trial Info
Start Date :
March 21 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 19 2024
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT05972408
Start Date
March 21 2021
End Date
January 19 2024
Last Update
June 10 2024
Active Locations (1)
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1
Mansoura University
Al Mansurah, Outside U.S./Canada, Egypt, 35561