Status:
RECRUITING
Neoadjuvant Treatment Real-world Clinical Outcomes in NSCLC
Lead Sponsor:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conditions:
Non-Small Cell Lung Cancer
Eligibility:
All Genders
18-85 years
Brief Summary
Despite the clinical success of immune checkpoint blockade (ICB), in neoadjuvant setting, there is still a lack of valid data for operable NSCLC in the real world. This study aim to compare the clinic...
Detailed Description
Although the application of neoadjuvant immunotherapy in NSCLC has brought a new treatment option to many patients, most evidence is based on interventional clinical trials, in which the participants ...
Eligibility Criteria
Inclusion
- Cytological or histological diagnosis of non-small cell lung cancer
- Patients who have previously undergone neoadjuvant immune checkpoint inhibitors and/or chemotherapy and then undergone radical surgery;
- Stage I-III non-small cell lung cancer (IASLC/UICC staging eighth edition);
- No previous history of malignant tumors and other malignant tumors at the same time, without any anti-tumor treatment;
- ECOG score 0-1, heart, lung, liver, brain and kidney function can tolerate surgery;
- At least one measurable lesion (RECIST v1.1);
- Age \>= 18 years old and \<= 85 years old;
- Be able to abide by the visits and related procedures stipulated in the program.
Exclusion
- Patients included in anti-tumor drug intervention or unblinded clinical trials, in which the treatment being administered is unknown.
- Prior surgery, radiotherapy or systemic therapy for NSCLC, including radiofrequency ablation, etc.
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
1500 Patients enrolled
Trial Details
Trial ID
NCT05974007
Start Date
January 1 2022
End Date
June 1 2026
Last Update
August 3 2023
Active Locations (1)
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1
National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, China, 100021