Status:
ACTIVE_NOT_RECRUITING
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust
Conditions:
TIA
Carotid Artery Plaque
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated w...
Detailed Description
Up till now our Lab has looked at Tregs and immune cells in the blood. The question remains whether low dose IL-2 can have the desired effect on Tregs in atherosclerotic plaques where they could alter...
Eligibility Criteria
Inclusion
- Presence of carotid stenosis on either ultrasound or CT scan.
- Planned to undergo carotid endarterectomy.
Exclusion
- Autoimmune disease
- Any regular immunosuppressive treatment \[Inhaled or topical steroids are permissible\]
- Modified Rankin Scale score of ≥4 at screening
- Known active hepatic disease or alanine aminotransferase (ALT) \> 2xULN
- Severe chronic kidney disease (defined as eGFR \< 30 ml/min/1.73m2)
- Allergy or intolerance to aldesleukin
- Signs or symptoms of active infection
- History of human immunodeficiency virus (HIV), hepatitis B or C
- Current malignancy requiring active treatment
- Vaccine within 4 weeks prior to screening or plans for vaccination during study period
- Women of child-bearing potential and pregnancy
- Women who are breast-feeding
- Clinically relevant medical or surgical conditions that, in the opinion of the
Key Trial Info
Start Date :
August 26 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05975554
Start Date
August 26 2023
End Date
September 1 2025
Last Update
May 30 2025
Active Locations (1)
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1
Addenbrookes Hospital
Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ