Status:
COMPLETED
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Conditions:
Post-Acute COVID-19
Post-Acute COVID-19 Infection
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection. Fibroblasts are involved in tissue remodeling and ...
Detailed Description
Rationale: The pathogenesis of post-acute COVID-19 with respiratory complaints remains unknown. We aim to explore the pulmonary pattern and fibrosis activity in patients with post-acute COVID-19 with ...
Eligibility Criteria
Inclusion
- Male patients \>18 years and female patients \>20 years discharged from hospital after PCR-confirmed COVID-19 infection.
- Previous ICU or ward admission with high flow nasal oxygen (HFNO) or mechanical ventilation.
- Persistent respiratory complaints (shortness of breath) at least 3 months after hospital discharge.
Exclusion
- Inability or unwilling to give informed consent.
- History of claustrophobia or feeling of inability to tolerate supine position for the PET/CT scans.
- Severe or significant comorbidity, defined as COPD GOLD stage II or higher and/or known interstitial lung disease.
- Women who are pregnant or breastfeeding.
Key Trial Info
Start Date :
June 9 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 17 2024
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT05981885
Start Date
June 9 2022
End Date
May 17 2024
Last Update
May 21 2024
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands, 9713GZ