Status:
RECRUITING
Avatar-mediated Therapy Versus Cognitive Behavioural Therapy for Persisting Experiences of Hearing Voices
Lead Sponsor:
Swinburne University of Technology
Collaborating Sponsors:
University of Copenhagen
University of Manchester
Conditions:
Auditory Hallucination
Psychotic Disorders
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to compare the effects of a new psychological therapy, Avatar Therapy, to the current standard therapy, Cognitive Behavioural Therapy (CBT), in improving outcomes in people li...
Detailed Description
Continually hearing critical, abusive or threatening voices (auditory verbal hallucinations, AVHs) is a major persisting and disabling symptom of psychotic disorders such as schizophrenia. Current tre...
Eligibility Criteria
Inclusion
- Schizophrenia-related disorder or a mood disorder with psychotic symptoms diagnosis confirmed using the Structured Clinical Interview for DSM (SCID)
- Experiencing current auditory verbal hallucinations as measured by the Positive and Negative Syndrome Scale (PANSS) item P3 ≥ 4
- Auditory verbal hallucinations present for at least one year
- AVHs include significant negative content (PSYRATS item 6 ≥ 2) and/or AVHs are distressing (PSYRATS item item 9 ≥ 2)
- Current treatment with antipsychotic medication, or has been treated with antipsychotic medication in the past, with at least two different antipsychotic compounds, and these have been discontinued due to insufficient treatment response and/or poor tolerability.
- Access to the internet and a computer or other device on which videoconferencing software can be used
- Sufficient fluency in English for meaningful participation
- Age 18 or over
- Ability to give informed consent
Exclusion
- Auditory verbal hallucinations attributable to a primary substance use disorder or organic disorder
- Estimated full scale IQ \< 70 (using the Test of Premorbid Functioning, TOPF)
- Within the last month or planned at the time of intake: a change of antipsychotic medication,
- Current or within the past 3 months receipt of individual psychological therapy for hearing voices, or receipt of electro-convulsive therapy or other brain stimulation treatment;
- AVHs in a language not spoken by the therapists.
Key Trial Info
Start Date :
August 8 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT05982158
Start Date
August 8 2023
End Date
June 1 2027
Last Update
November 22 2024
Active Locations (1)
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1
Swinburne University of Technology
Hawthorn, Victoria, Australia, 3122