Status:
UNKNOWN
Brain MRI for Knee OA
Lead Sponsor:
Toronto Rehabilitation Institute
Collaborating Sponsors:
McMaster University
Conditions:
Chronic Pain
Central Sensitisation
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years. OA is degenerative joint disease that has joint cartilage break ...
Detailed Description
Chronic pain and knee osteoarthritis - context and gap Chronic pain is a debilitating concern that can affect the health, employment, and lifestyle of individuals and puts a tremendous strain on the ...
Eligibility Criteria
Inclusion
- Clinical diagnosis and radiographic evidence of knee OA (by rheumatologist).
- For the two experimental groups (Groups OA-Knee and OA-Knee+Body), participants must have experienced chronic pain related to their knee OA (\>3 months) on most days of each month.
- Participants in Group OA-Knee+Body must:
- Exhibit chronic knee pain and widespread bodily pain at \>3 Michigan Body Map regions.
- Meet the Kosek criteria for nociplastic pain: i) the duration/regionality/type of pain, ii) history of hypersensitivities, iii) comorbidity identification, and iv) evoked pain hypersensitivity \[19\]
- Participants must be able to speak and understand English.
Exclusion
- Unable to provide consent (e.g., poor English language skills, etc.)
- History of liver or kidney disease
- MRI contraindications:
- Pacemaker
- Stent
- Joint prothesis
- Implanted devices
- Claustrophobia
- Pregnant
- Permanent piercings
- Chronic/abusive use of alcohol and/or illicit drugs
- Previous clinical diagnosis of fibromyalgia, a multisite pain disorder, a systemic inflammatory disorder (e.g., rheumatoid arthritis, myopathy), depression, post-traumatic stress disorder
- Previous stroke or moderate/severe traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage
- Use of psychotropic medications
- Control subjects (Group OA-PF) also cannot have a history of chronic pain or knee pain caused by osteoporosis or osteoarthritis
- Total knee replacement
- Pregnant or chance of being pregnant
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2025
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT05986513
Start Date
September 1 2023
End Date
August 31 2025
Last Update
August 18 2023
Active Locations (2)
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1
Imaging Research Centre, St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8P 2J5
2
Toronto Rehabilitation Institute
Toronto, Ontario, Canada, M5G 2A2