Status:
RECRUITING
Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Prosthetic Valve Endocarditis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether...
Detailed Description
In patients medically treated for prosthetic valve infection (PVE), identification of persistent infection or of cure could be very useful to 1/ patients referral to high-risk surgery, 2/ initiation o...
Eligibility Criteria
Inclusion
- "Inclusion criteria:
- Patient aged 18 or over;
- Have a prosthetic valve implanted surgically or by catheter for at least 3 months;
- Presenting a definite IE on a prosthetic valve (ESC definition in force);
- Having benefited from an FDG-PET examination for diagnostic purposes as part of the treatment revealing pathological hyperuptake at the level of the prosthetic valve AND carried out \<15 days after the start of antibiotic therapy for infective endocarditis;
- Absence of cardiac surgical intervention performed for the current episode of AE or planned before the end-of-treatment FDG-PET
- Exclusion criteria:
- Patient under legal protection, guardianship or curators;
- Pregnancy, breastfeeding;
- Patient not affiliated to a health insurance scheme or not a beneficiary of a social security scheme;
- Simultaneous participation in a study on FDG-PET;
- Absence of informed consent signed by the patient."
Exclusion
Key Trial Info
Start Date :
April 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05989152
Start Date
April 17 2025
End Date
December 1 2027
Last Update
August 5 2025
Active Locations (1)
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1
Hôpital Bichat-Claude Bernard
Paris, France, France, 75018