Status:
UNKNOWN
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
Lead Sponsor:
McMaster University
Collaborating Sponsors:
Alzheimer's Society of Brant, Haldimand Norfolk, Hamilton Halton
Conditions:
Cerebrovascular Function
Cognition
Eligibility:
All Genders
55-75 years
Phase:
NA
Brief Summary
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood fl...
Eligibility Criteria
Inclusion
- between the ages of 55 and 70
- presence of subjective memory complaints as determined by the Prospective- Retrospective Memory Questionnaire
- cognitively normal, e.g. score ≥26 on the Montreal Cognitive Assessment
Exclusion
- Presence of obesity (body mass index \> 30 kg/m\^2)
- Presence of known cardiovascular disease
- Presence of type 2 diabetes
- History of cardiovascular events requiring hospitalization in the past 3 years (e.g., heart attack, stroke)
- History of concussion(s) with persistent symptoms
- Currently following a ketogenic diet and/or taking ketone body supplements
- Diagnosis of any form of Alzheimer's disease or dementia
Key Trial Info
Start Date :
October 25 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05992571
Start Date
October 25 2023
End Date
August 1 2024
Last Update
December 1 2023
Active Locations (1)
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1
McMaster University
Hamilton, Ontario, Canada, L8S 4K1