Status:
RECRUITING
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
Lead Sponsor:
Arkansas Children's Hospital Research Institute
Collaborating Sponsors:
Cargill
Conditions:
Adiposity
Insulin Sensitivity
Eligibility:
All Genders
8-12 years
Phase:
NA
Brief Summary
This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function rel...
Detailed Description
Up to 150 children will be enrolled in the study to achieve a final sample of 90 completers (30 per group). The proposed study will be an 8 to 14-week, three-arm, randomized, controlled, blinded trial...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age 8-12 years
- Normal weight: BMI percentile ≥5th to \<85th
- Excessive weight: BMI percentile ≥ 85th and \<140% of the 95th percentile or BMI ≥35 to \<40 kg/m2
- Current consumption of sugar sweetened beverages (≥2 times /wk)
- Low consumption of non-nutritive sweeteners (≤ 3 time/wk)
- Willingness to consume experimental products Exclusion Criteria
- Children with class 3 obesity (i.e., BMI ≥ 140% of the 95th percentile or BMI ≥ 40.0 kg/m2)
- Dislike of experimental beverage taste (assessed at initial visit)
- Asthma that requires daily use of inhalers to keep symptoms under control.
- Asthma that requires use of rescue inhalers (e.g., albuterol) \>2 days per week
- Exercise induced asthma.
- Autism spectrum disorder (e.g., Autistic disorder, Rett disorder, Asperger disorder, childhood disintegrative disorder, pervasive developmental disorder not otherwise specified (PDD-NOS).
- Attention deficit hyperactivity disorder (ADHD) currently under medication.
- Oppositional defiant disorder (ODD).
- Epilepsy.
- Cancer.
- Chronic kidney disease.
- Endocrine disorder (e.g., hypothyroidism and growth hormone deficiency).
- Autoimmune diseases (e.g., lupus, thyroiditis, juvenile idiopathic arthritis)
- Bleeding disorders (e.g., hemophilia)
- Chronic infections (e.g., HIV, hepatitis B, hepatitis C).
- Mental health disorders (e.g., depression and anxiety).
- Type 2 and type 1 diabetes mellitus.
- Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest.
- If, during the screening or consent process, the parent or child expresses refusal to have blood drawn. However, participants may remain in the study if after initially agreeing to the blood draw and enrolling they change their minds and choose not to allow blood draws or if blood draws are unsuccessful.
- Dislike of study products assessed at initial visit.
- Fasting glucose ≥126 mg/dl at enrollment.
- Fasting A1C ≥6.5% at enrollment
- Less than 2 months since completion of antibiotics
Exclusion
Key Trial Info
Start Date :
September 19 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT05992688
Start Date
September 19 2023
End Date
November 30 2026
Last Update
December 22 2025
Active Locations (2)
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1
Arkansas Children's Nutrition Center
Little Rock, Arkansas, United States, 72202
2
Arkansas Children's Nutrition Center
Little Rock, Arkansas, United States, 72202