Status:
COMPLETED
Intensive Drug Therapy for Ischemic Stroke Caused by Severe Intracranial Arterial Stenosis
Lead Sponsor:
Shanghai Yueyang Integrated Medicine Hospital
Conditions:
Ischemic Stroke
Eligibility:
All Genders
35-80 years
Brief Summary
To observe the safety and efficacy of intensive drug therapy for ischemic stroke caused by severe intracranial arterial stenosis.Patients with acute stroke caused by intracranial arterial stenosis (st...
Detailed Description
Patients (35 to 80 years ) with acute ischemic stroke, who can be treated within 72 hours of symptom onset will be enrolled. Patients fulfilling all of the inclusion criteria and none of the exclusion...
Eligibility Criteria
Inclusion
- Age between 35 and 80 years;
- Onset \<72 hours;
- New-onset ischemic stroke confirmed by skull magnetic resonance diffusion weighted imaging (MR-DWI);
- Severe ICAS (stenosis ≥70%) indicated by time-of-flight magnetic resonance angiography (TOF-MRA).
Exclusion
- Ischemic stroke caused by other etiological factors (e.g., cardio-embolism, arterial dissection, vasculitis, etc.);
- Post-infarction hemorrhagic transformation and intraplaque hemorrhage as indicated by imaging examination;
- Contraindications to aspirin, clopidogrel, or atorvastatin;
- Intracranial hemorrhage within 3 months and a recent history of surgery or trauma;
- Severe organ impairment, liver insufficiency, and renal insufficiency;
- Complicated with tumors or hemorrhagic diseases;
- Use of drugs forbidden to use in combination after onset, including other antiplatelet drugs, anticoagulants, thrombolytic drugs, and drugs affecting antiplatelet agents and statin metabolism.
Key Trial Info
Start Date :
February 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 30 2023
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT05996978
Start Date
February 1 2020
End Date
April 30 2023
Last Update
August 18 2023
Active Locations (1)
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1
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Shanghai, China