Status:
UNKNOWN
Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's Hospital
Lead Sponsor:
Cairo University
Conditions:
Dobutamine, Milrinone , Pediatrics , Low Cardiac Output
Eligibility:
All Genders
1-14 years
Phase:
NA
Brief Summary
The aim of the study is to detect wither dobutamine or milrinone have a privilege in the management of low cardiac output pediatric patients over the other.
Detailed Description
Randomized controlled trials (RCTs) enrolling critically ill patients with low cardiac output syndrome (LCOS) admitted at pediatrics emergency and intensive care units ,Cairo University Children's Hos...
Eligibility Criteria
Inclusion
- 1-Patients from age of 1 month to 14 years old of both sexes.
- 2-Patients presenting with fluid refractory shock with low cardiac output state, evidenced by sustained hypotension (systolic blood pressure below 5th percentile for age) and end organ dysfunction (altered level of consciousness, renal or hepatic dysfunction)
- 3-Clinical evidence of systemic and/or pulmonary congestion despite use of vasodilators and/or diuretics
- 4-Refractory heart failure requiring admission for inotropic support.
Exclusion
- 1-All other causes of pediatric shock not in need for inotropic support (eg.isolated hypovolemic shock, anaphylaxis,….)
- 2 - patients not fit for randomization needing specific line of management (eg. Sever hypotension patients with good filling pressure unfit for milrinone , patients previously known having sever pulmonary hypertension not fit for dobutamine ,…)
- 3-post cardiac surgery patients with low cardiac output manifestation.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05999487
Start Date
October 1 2023
End Date
May 1 2024
Last Update
August 21 2023
Active Locations (1)
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1
Cairo University Children'S Hospital
Giza, Egypt, 11511