Status:
NOT_YET_RECRUITING
Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects
Lead Sponsor:
Indiana University
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
45+ years
Phase:
NA
Brief Summary
This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of coronary artery dis...
Detailed Description
This study will establish the safe and tolerable level of high PC02 and low P02 for future studies as potential stressors for coronary artery disease assessment.
Eligibility Criteria
Inclusion
- Adults ≥ 45 years of age
- No known cardiac disease
Exclusion
- Low blood pressure (systolic blood pressure \< 100 mmHg)
- Inability to voluntarily increase their breathing rate if prompted to do so
- Persons with the inability to lie supine for 30-40 minutes
- Persons who are pregnant, nursing, or implanted with intrauterine devices (IUD's)
- Persons with significant neurological, pulmonary, renal or hepatic disease
- Persons who have an abnormal cardiac rhythm or resting heart rate \>100/min
- Inability or unwillingness to provide informed consent
Key Trial Info
Start Date :
January 10 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 15 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06000540
Start Date
January 10 2026
End Date
June 15 2027
Last Update
August 22 2025
Active Locations (1)
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1
IU Health Methodist Hospital
Indianapolis, Indiana, United States, 46202