Status:
UNKNOWN
Brain Substrate Switch to Ketones and Lactate
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
University of Otago
Conditions:
Metabolic Diseases
Aging Problems
Eligibility:
All Genders
19-40 years
Phase:
NA
Brief Summary
The brain is constantly active and energetically expensive, making up a quarter of the body's energy budget despite occupying only 2% of its mass. To fuel this incessant activity, the brain relies on ...
Detailed Description
Objectives: Primary: • To determine if brain ketone and lactate metabolism cause the beneficial neurotrophic responses associated with fasting and exercise, respectively. Secondary: • To determine...
Eligibility Criteria
Inclusion
- Regularly physically active, as determined via questionnaires
Exclusion
- Current smokers
- Acute bronchial asthma, chronic obstructive airway or status asthmaticus
- Obese (body mass index greater than 30 kg m-2)
- Requiring daily prescription medications that may affect responses to exercise, e.g., anti-hypertensives, anti-arrhythmogenics, inhalers
- History of disease/dysfunction that could cause complication with exercise, e.g. cardiovascular, respiratory, neurological or musculoskeletal diseases
- Irregular or absent menstrual cycle (females)
- Pregnant or may suspect pregnancy, or post-menopausal (females)
- Any unexpected adverse responses to pre-experimental exercise tests
- Any contraindication to a lumbar subarachnoid access
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2024
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06000605
Start Date
October 1 2023
End Date
January 1 2024
Last Update
August 24 2023
Active Locations (1)
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1
University of British Columbia - Okanagan Campus
Kelowna, British Columbia, Canada, V1V1V7