Status:
ENROLLING_BY_INVITATION
Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Lead Sponsor:
Kernel
Conditions:
Depression
Major Depressive Disorder
Eligibility:
All Genders
18-75 years
Brief Summary
The purpose of the current study is to perform a unified, homogeneous data collection protocol that includes a large cohort of patients undergoing different treatment options for Major Depressive Diso...
Eligibility Criteria
Inclusion
- Ketamine cohort
- Adult between the ages of 18 - 65, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for ketamine treatment and agrees to receive ketamine treatment
- Agrees to start ketamine treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not received a ketamine treatment course in the past 12 months
- Has not received a TMS treatment course in the past 3 months
- Ability to consent for themselves
- Fluency in English (speaking and reading)
- SPRAVATO cohort
- Adult between the ages of 18 - 75, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for SPRAVATO treatment and agrees to receive SPRAVATO treatment
- Agrees to start SPRAVATO treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not received a ketamine or SPRAVATO treatment course in the past 12 months
- Has not received a TMS treatment course in the past 3 months
- Ability to consent for themselves
- Fluency in English (speaking and reading)
- TMS cohort
- Adult between the ages of 18 - 65, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for TMS treatment and agrees to receive TMS treatment
- Agrees to start TMS treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not received a TMS treatment course in the past 12 months
- Has not received a ketamine or SPRAVATO treatment course within the last 3 months
- Ability to consent for themselves
- Fluency in English (speaking and reading)
- Antidepressants cohort
- Adult between the ages of 18 - 65, inclusive at time of enrollment
- Primary diagnosis of MDD as defined by DSM-5
- Determined by clinic to be eligible for antidepressant treatment and agrees to receive antidepressant treatment
- Agrees to start antidepressant treatment in conjunction with study participation to capture pre-treatment measurements accurately
- Has not taken antidepressants in the past 3 months
- Has not received a TMS, SPRAVATO, or ketamine treatment course in the past 3 months
- Ability to consent for themselves
- Fluency in English (speaking and reading)
Exclusion
- Is or may be pregnant (for participant of childbearing potential \[POCBP\]), even if they have been cleared to receive the depression treatment
- Unable or unwilling to wear the TD-fNIRS headset
- Has had ECT in the past 3 months
- Major visual or auditory deficits that would prevent study task completion
- Hospitalizations and/or unstable health/medical condition/treatment in the last 30 days
- Major medical illnesses and psychiatric conditions including:
- Alzheimer's/Mild Cognitive Impairment
- Parkinson's disease
- Motor neuron diseases
- Multiple Sclerosis
- Brain Tumor
- Stroke
- Encephalitis
- Meningitis
- Epilepsy
- TBI with serious results (coma, unconscious for \>2 hrs, or skull fracture)
- Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis)
- Any other clinically significant medical condition or circumstance that, in the opinion of the Investigator, could affect patient safety, preclude evaluation of response, interfere with the ability to comply with study procedures, or prohibit completion of the study
- Not an appropriate candidate for the study in the judgment of the investigator(s)
Key Trial Info
Start Date :
August 14 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
540 Patients enrolled
Trial Details
Trial ID
NCT06002100
Start Date
August 14 2023
End Date
August 1 2026
Last Update
December 12 2025
Active Locations (10)
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1
BrainHealth Solutions
Costa Mesa, California, United States, 92626
2
Kadima Neuropsychiatry Institute
La Jolla, California, United States, 92037
3
Kaizen Brain Center, LLC
La Jolla, California, United States, 92037
4
Bespoke Treatment
Los Angeles, California, United States, 90012